Adolf Guyer-Zeller (1 May 1839 in Neuthal bei Bauma - 3 April 1899) was a Swiss entrepreneur.
He was the son of an owner of spinning mill and creator of a textile export trade in Zürich. After the death of his father, he led the company. He studied at the Swiss Federal Institute of Technology in Zürich.
Later he turned his attentions to what had become a booming business, the building of railways in Switzerland. He became, among other things, a president of the Swiss Northeastern Railway (NOB). Guyer-Zeller was also the founder of Jungfrau Railway, (JB) and the Uerikon-Bauma Railway (UeBB). In order to finance the JB, he founded the Bank Guyerzeller AG (now HSBC Guyerzeller Bank AG) in 1894, which became fully owned by HSBC in 2004.